According to Kekalf, The Vawlent, the phrase 'Lock in like a mfer' suggests a strategy of committing to a cryptocurrency position decisively. This approach may be relevant for traders considering long-term holding strategies in volatile markets, especially when dealing with NFTs. Kekalf's statement highlights the importance of firm decision-making to optimize trading outcomes in the NFT space. (Source: Kekalf, The Vawlent on Twitter)